Polygenic association between attention-deficit/hyperactivity disorder liability and cognitive impairments
نویسندگان
چکیده
منابع مشابه
Association between polygenic risk scores for attention-deficit hyperactivity disorder and educational and cognitive outcomes in the general population
Background Children with a diagnosis of attention-deficit hyperactivity disorder ADHD) have lower cognitive ability and are at risk of adverse educational outcomes; ADHD genetic risks have been found to predict childhood cognitive ability and other neurodevelopmental traits in the general population; thus genetic risks might plausibly also contribute to cognitive ability later in development an...
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Background and Method: This study tested hypotheses about patterns of familial association between attention deficit disorder (ADD) and anxiety disorders among 356 first-degree relatives of 73 clinically referred children with ADD and 26 normal comparison children. Through structured diagnostic interviews with trained raters, relatives were assessed for adult and childhood psychopathology. Afte...
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Attention-deficit/hyperactivity disorder (ADHD) and autism spectrum disorder (ASD) are commonly comorbid, share genetic liability, and often exhibit overlapping cognitive impairments. Clarification of shared and distinct cognitive effects while considering comorbid symptoms across disorders has been lacking. In the current study, children ages 7-15 years assigned to three diagnostic groups:ADHD...
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BACKGROUND Attention-deficit/hyperactivity disorder (ADHD) is an important modulator of cognitive and social functioning in cocaine addiction but it is unclear whether ADHD symptoms and cocaine use display mutually aggravating interaction effects on cognition, social functioning, and depressive symptoms. Therefore, we investigated the interaction of cocaine use and adult ADHD on social and non-...
متن کاملattention-deficit hyperactivity disorder and adult schizophrenia Shared polygenic contribution between childhood
Large-scale genetic association studies have identified replicable susceptibility alleles for some psychiatric phenotypes. 1 This includes both common and rare variants. A striking finding has been that susceptibility variants identified to date often confer susceptibility to more than one of the traditional clinical phenotypes , a finding that has the potential to increase understanding of the...
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ژورنال
عنوان ژورنال: Psychological Medicine
سال: 2021
ISSN: 0033-2917,1469-8978
DOI: 10.1017/s0033291720005218